AGT and cardiovascular disorder: Interestingly, it has been reported that EndMT contributes to the development of atherosclerotic lesions, which could explain the role of air pollution in the development and progression of cardiovascular disease (116), where upregulation of angiotensinogen and the angiotensin-converting enzyme has been shown, resulting in increased circulating angiotensin II and activation of the angiotensin II receptor type 1, thus favoring vascular contractility (89, 117).