Probiotic intervention or not, age, gender, BMI, waist circumference, blood pressure, liver function, blood lipid, blood glucose, serum insulin and HbA1c were used as covariates, and results showed that 30-minute post-glucose load insulin level was a factor affecting the conversion of IGT to T2DM (HR=0.954, 95%CI 0.915-0.994, P =0.026) (Figure 3). The gene discussed is INS; the disease is type 2 diabetes mellitus.