In the heart of male rodents with T2DM, SGLT2 inhibition decreases ROS production (135) and also increases the expression of nuclear respiratory factor 1 (NRF1) and PPARγ coactivator 1-α (PGC1α) (136), which positively regulate mitochondrial biogenesis (134). This evidence concerns the gene NRF1 and type 2 diabetes mellitus.