To further highlight the link between dysregulated autophagy and inflammation, it was demonstrated that activation of the NLRP3 inflammasome and increased expression of inflammatory markers, including F4/80, tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-10, IL-18, monocyte chemoattractant protein 1 (Mcp-1), and caspase-1 was linked with Atgl-deficiency in mice (13). Here, TNF is linked to hyperinsulinemic hypoglycemia, familial, 4.