,59 Furthermore, it also appears that the transcriptional and functional dichotomies of CAFs in MOVCAR 5009-bearing WT and transgenic mice were less dependent on FAP and PDPN antigen expression because both markers were detected on pro-inflammatory and protumorigenic CAFs, emphasizing a challenge in their targeting strategies during in vivo tumor evolution.60 The gene discussed is PDPN; the disease is neoplasm.