Prompted by the findings that inhibition of the interaction of CXCL12 with CXCR4 on CAFs leads to elimination of tumor cells through accumulation of cytotoxic CD8+ T cells,14 we next examined the effect of OV-CXCR4-A treatment on tumor-associated lymphocytes (TALs) in the peritoneal TME of WT and transgenic mice. Here, CD8A is linked to neoplasm.