Although the mechanisms responsible for the nearly complete depletion of CAFs by OV-CXCR4-A are not fully understood, we hypothesize that they could be related to apoptosis of CXCR4-expressing CAFs after binding to the CXCR4 antagonist released from OV-CXCR4-A-infected tumor cells, as reported previously.11 This evidence concerns the gene CXCR4 and neoplasm.