CXCR4 and neoplasm: As depicted in Figure 8G, CD8+ T cells isolated from OV-CXCR4-A-treated transgenic mice exhibited reduced cytotoxic activity compared with their counterparts from tumor-bearing WT mice (p = 0.03), which is consistent with increased expression of genes associated with tumor-induced exhaustion and a reduced level of TCRTag-I tetramer binding.