Our results showed that transient antigen-specific reversal of CD8+ T cell tolerance to TAg in tumor-bearing TgMISIIR-TAg-Low mice was achieved by OV-CXCR4-A-induced immunogenic cell death and transcriptional reprogramming of M2 tumor-associated macrophages (TAMs) associated with effective targeting of immunosuppressive CAFs by the armed virus. Here, CXCR4 is linked to neoplasm.