Here, we compared the antitumor activity of CD8+ T cells against SV40 T antigen (TAg)+ murine ovarian carcinoma (MOVCAR) 5009 ovarian carcinoma (OC) grown orthotopically in TAg-naive syngeneic wild-type (WT) C57BL/6 mice to responses generated in non-tumor-prone C57BL/6 TgMISIIR-TAg-Low transgenic mice expressing the TAg protein in epithelial cells lining the fallopian tubes under transcriptional control of the Müllerian inhibiting substance type II receptor gene promoter.22 Here, CD8A is linked to ovarian carcinoma.