This profile of gene expression in the tolerogenic TME was concomitant with the upregulation of key markers of M2 macrophages and MDSCs that mediate T cell suppression (Arg1, Retnla, and Chil3),35,36,37 promote CD4+Foxp3+ Treg cell expansion (Cd209a),38 as well as foster angiogenesis and modify tumor-associated inflammatory cell migration and function (Spp1).39 This evidence concerns the gene SPP1 and neoplasm.