For example, the lymphoid clusters (T cells/NK T cells) were prominent in OV-CXCR4-A-treated tumors but underrepresented in control tumor-bearing mice, opposite to the cluster depicting fibroblasts, endothelial, and tumor cells prevailing in untreated tumors, whereas the M2 macrophage cluster was present only in the untreated group of TgMISIIR-TAg-Low mice. Here, CXCR4 is linked to neoplasm.