In contrast, CAFs in TgMISIIR-TAg-Low mice expressed genes encoding protein and transcription factors involved in cancer progression by regulating the dynamics of cytoskeletal constituents (S100a6 and its binding partner, Anx2),45,46 activating the Wnt signaling pathway involved in cancer stemness and therapy resistance (Wnt4),47 and contributing to mutant p53 gain of function (an Erg1 transcription factor implicated in growth control and apoptosis).48 This evidence concerns the gene ANXA2 and cancer.