CXCR4 and neoplasm: Progression of tumor growth, presented in Figure 7C, left panel, revealed that CAFs derived from tumor-challenged transgenic mice exhibited higher protumorigenic activities compared with their WT counterparts because a significant increase in tumor load was observed on days 9 and 19 in control (Figure 7C, right panel; p = 0.02 and p = 0.03, respectively) as well as OV-CXCR4-A-treated mice (p = 0.007 and p = 0.02, respectively).