BMPR2 and pulmonary arterial hypertension: Phenotypically, BMPR2-deficientpulmonary artery endothelial cells display increased apoptosis [38], disruptedvasodilator/vasoconstrictor homeostasis [41], endothelial-to-mesenchymaltransition (EndoMT) [42], and dysregulated metabolism [43, 44, 45]—alterations whichmirror those seen in cultured PAECs from PAH patients in general.