CYP19A1 and Pulmonary arterial hypertension associated with portal hypertension: Implicating a pathogenic role for estrogens,a polymorphism in CYP19A1 was associated with increased estradiol levelsand the presence of portopulmonary hypertension (PoPH)—a subgroup of PAH—inpatients with advanced liver disease, while PoPH was also associated withincreased levels of 16-estrogens [84].