B-type natriureticpeptide (BNP) is perhaps the most widely-used biomarker in PAH, a preformedpeptide release from the ventricle during periods of increased wall tension thatcorrelates with hemodynamic derangements [255], RV systolic function [256], andmortality [257]. The gene discussed is NPPB; the disease is pulmonary arterial hypertension.