SCUBE1 and pulmonary arterial hypertension: In another small study, our group proposedSignal peptide, CUB domain and EGF like domain containing 1 (SCUBE1) as amechanistic biomarker of PAH based on its differential expression in inducedpluripotent stem cell endothelial cells (iPSC-Ecs) derived from affected andcarrier BMPR2 mutant heterozygotes.