Recent discoveries haveshed light onto the involvement of lncRNAs in PAH pathobiology; notably, tyrosinekinase receptor–inducing lncRNA (TYKRIL) was recently shown to be upregulated inPASMCs and pericytes from PAH patients and promotes cellular proliferation byinterfering with p53-mediated transcriptional repression of platelet-derivedgrowth factor receptor beta (PDGFRβ) [172]. The gene discussed is PDGFRB; the disease is pulmonary arterial hypertension.