GLS and ovarian cancer: In experimental PAH, glutaminase (GLS1) is upregulated in ayes-associated protein (YAP1)-dependent fashion in order to generatemacromolecular precursors and sustain proliferation, with inhibitors of theseproteins leading to prevention and reversal of rodent PH [118, 119, 120].Interestingly, NO has been shown to promote Warburg-type physiology andglutaminolysis in ovarian cancer cells, although it is unknown whether comparablemechanisms translate to pulmonary vascular cell types [121].