KDR and pulmonary arterial hypertension: In rodent models of PH, thephenotype triggered by Sugen (SU5416) as a model of PAH was attributed to itsactivation of AhR rather than inhibition of VEGFR2 as previously accepted [71].AhR activation provoked inflammation and PH in animal models, while plasmaagonistic AhR activity was higher in PAH patients than in healthy controls [70].If this finding is upheld, it would suggest a role for countless additionalenvironmental xenobiotics in the development of PAH.