Another carbamate, carbendazim, which may also be a metabolite of methyl thiophanate and benomyl [90], increases the expression of PPARγ, FAS, hexokinase 1 (HK1) (glycolysis), and PK, in addition to altering the gut microbiota, which decreases the genus Firmicutes and Bacteroidetes, which is associated with obesity [91]. The gene discussed is HK1; the disease is obesity due to melanocortin 4 receptor deficiency.