Fittingly, without knowledge of the clinical information at the time of testing, the DiagMMR results showing deficient MMR correlated well with patients with multiple cancers in the family and MSI-H tumor phenotype, while the samples shown to be MMR proficient were from individuals with less LS-supportive clinical data, albeit the LS-indicative tumor IHC finding. The gene discussed is MRC1; the disease is neoplasm.