This increased tumor infiltration in the OAd-MSC TLR4−/− group was also observed in regard to innate immune populations, as the group treated with OAd-MSC TLR4−/− showed significant higher density of myeloid cells and macrophages than those treated with either PBS or OAd-MSC WT (Fig. 2J). Here, TLR4 is linked to neoplasm.