CD4 and neoplasm: Cross-presentation is also one of the potential major mechanisms for MHC-II restricted epitopes to induce CD8+ CTL responses, macro-autophagy of the exogenous antigens in tumor cells is essential process for antigen sequestration and delivery to dendritic cells for cross-presentation (42), CD4+ Th cells itself can also modify the APC, convert it into an effective stimulator for the successful cross-priming (43).