In turn, the lowest SPON1 levels were detected in the RRD group, confirming this protein as a good discriminatory biomarker when compared to AMD (AUC=0.81, p-value=6.46E-03) and ERM groups (AUC=0.80, p-value=7.65E-03), but not from DR. The gene discussed is SPON1; the disease is age-related macular degeneration.