APP and amyloidosis: These two proteins, as well as complement components (e.g., CFH, C2), regulators of complement cascades (clusterin (CLU)) and amyloidosis proteins (amyloid-beta precursor protein [APP], CYTC3) are also associated to macular degeneration and pathological processes, such as choroidal neovascularization, geographic atrophy, and retinal drusen.