In contrast, complement C1s subcomponent was found to be downregulated in PDR compared to ERM/dry AMD in LFQ, as well as lower levels of complement factor D (previously reported to be up-regulated in DR/PDR (34, 48, 74)) and complement factor I were found in PDR compared to ERM and dry AMD, respectively. This evidence concerns the gene C1S and dry age related macular degeneration.