PEDF is mainly secreted by the RPE and is a potent inhibitor of angiogenesis, although it participates in other processes such as neuronal differentiation in retinoblastoma cells, inhibits retinal inflammation, and protects retinal neurons from light-induced damages, oxidative stress, and glutamate excitotoxicity (90, 91). This evidence concerns the gene SERPINF1 and retinoblastoma.