Among several families of PRRs, the nucleotide-binding domain and leucine-rich repeat receptors (NLRs), the absent in melanoma 2-like receptors (ALRs) and pyrin have been described to form the expanding inflammasome family, which includes the NLR family pyrin domain containing 1 (NLRP1), 3 (NLRP3), 6 (NLRP6), 7 (NLRP7), 9b (NLRP9b), NLR-family CARD-containing protein 4 (NLRC4) and 5 (NLRC5), AIM2, IFI16 and pyrin canonical inflammasomes (1–3). Here, NLRP1 is linked to melanoma.