In vitro, human RA LSCs express less CXCL12, and secrete less CCL19, CCL21 and CXCL13 upon stimulation with TNFα and LTα1β2 (56), potentially affecting migration, survival and selection of immune cells during the onset of RA (Figure 2C). The gene discussed is CXCL13; the disease is rheumatoid arthritis.