Knowing that dendritic cells, macrophages (76), FDCs (77, 78), medRCs (44) and possibly MRCs (79) can secrete BAFF/APRIL, high concentrations of BAFF/APRIL in peripheral blood may reflect altered BAFF/APRIL secretion by the stroma niche of GCs, supporting the local expansion and survival of autoreactive B cells in CVID patients with autoimmune dysregulations (Figure 2E). This evidence concerns the gene TNFSF13B and common variable immunodeficiency.