Following these results, it has been well reviewed that cytokines associated with Th2 inflammatory response such as IL4 and IL13 inhibit the secretion of several proinflammatory cytokines such as IL6, IL1B, IL1α, IL12, and TNF-α, which play a central role in the pathogenesis of COVID-19 and hyperinflammation (160). This evidence concerns the gene TNF and COVID-19.