COS inhibited polarization of M1 and M2 macrophages;COS inhibited JAK2/STAT1 pathway on M1 macrophages and JAK1/STAT6 pathway on M2 macrophages;3. COS rescued mice from hepatic fibrosis, marked by decreased deposition of extracellular matrix and histological lesions. Here, STAT1 is linked to Hepatic fibrosis.