However, hepatocyte-derived exosomes mediated TLR3 activation in HSCs and increased IL-17 production from γδ T cells, and the IL-17 strongly stimulated the expression of a-SMA, TGF-β, IL-6, and collagen type I-α1 in HSCs and aggravated liver fibrosis (73). The gene discussed is TGFB1; the disease is Hepatic fibrosis.