Th17 cells are helper T cells differentiated from Th0 cells stimulated by IL-6 and IL-23, which can secrete a large number of pro-inflammatory factors such as IL-17 and IL-22, activate TNF or Fas/FasL pathway to mediate hepatocyte apoptosis, and activate HSCs to promote the development of hepatic fibrosis (104, 105). The gene discussed is TNF; the disease is Hepatic fibrosis.