MYD88 and systemic lupus erythematosus: Additionally, neither of the two abovementioned suppressive, MyD88-independent regulatory roles of TLR9 rely on the absence of anti-DNA antibodies, as neither of these mice produce anti-DNA antibodies, yet lupus is substantially ameliorated in Tlr9K51E and Tlr9P915H mice compared with Tlr9−/− mice (17).