On the contrary, cytotoxic CD8+ T cells play a crucial role in tumor immunosurveillance and elicit anti-tumor immune response by secreting interferon (IFN)-γ and granzyme B (GZB) (136).Rao et al., have demonstrated that AMPK regulates protein phosphatase activity, which controls survival and function of CD8+ T cells, thereby enhancing their role in tumor immunosurveillance (95). This evidence concerns the gene CD8A and neoplasm.