AICAR-mediated induction of apoptosis and prevention of migration and invasion is dependent on the AMPK/mTOR axis.AICAR radiosensitizes prostate cancer cells to radiotherapy.AICAR induces necrosis in prostate cancer cells in an AMPK-independent manner.AMPK activation induces apoptosis of DU-145 cells via generation of ROS and activation of c-Jun. Here, PRKAA2 is linked to prostate cancer.