The compound also inhibited ribosomal 6 kinase (RSK) family proteins.BAY-3827 displayed excellent anti-proliferative effects against androgen-dependent prostate cancer cell lines by blocking HMGCR, fatty acid synthase (FASN) and PFKFB2, all of which are strongly up-regulated by androgen treatment (128). This evidence concerns the gene FASN and Familial prostate cancer.