The tumor-suppressive function of AMPK might be overpowered by intracellular stress or oncogenic signals in malignant cancer cells (116).For instance, previous reports suggest that the activation of AMPK as a result of stress induced by glucose depletion or hypoxia enables tumor cells to become more resistant to metabolic stress (113, 117–119). The gene discussed is PRKAA1; the disease is neoplasm.