By study the plasma of 23 RPs (CD4+ T-cell count < 350 cells/μl within 1 year of infection) and 21 “normal progressors” (NPs; CD4+ T-cell count > 500 cells/μl after 1 year of infection), eleven lipid metabolites were identified that could distinguish most of the RPs from NPs using an unsupervised clustering method. Here, CD4 is linked to infection.