Although several studies suggest that ω-3 EpFAs are more potent in specific biological effects including angiotensin-II-dependent hypertension, nociception and autophagy, numerous studies have suggested that EpFAs generated from different PUFAs could play very different roles and the effects from two different subclasses of epoxy fatty acids could oppose each other (106–121). This evidence concerns the gene AGT and Hypertension.