Pathogenetically, CD has been linked to development of the following main types of autoantibodies, namely IgA autoantibodies against tissue and epidermal transglutaminases (TG2, TG3), IgA- and IgG- autoantibodies against deaminated gliadine peptides (dGP) and IgA autoantibodies against the endomysium (EMA) (9). The gene discussed is CD79A; the disease is Cowden disease.