It has been suggested that DH develops as a result of prolonged gluten exposure and an untreated CD, however no data exist on why antibodies against TG2 and TG3 develop in parallel, or if TG3 merely becomes targeted via gradual loss of antigen specificity against TG2 in a subset of individuals with CD (14). The gene discussed is TGM2; the disease is dermatitis herpetiformis, familial.