NRP1 and hepatocellular carcinoma: NRP1, serving as a key factor of SARS-CoV-2 virus infection (41), could increase the susceptibility of cancer patients to SARS-CoV-2 virus and targeting (42), and its overexpression is associated with poor prognosis in bladder cancer cells and hepatocellular carcinoma, and inhibiting its expression could promote tumor cell apoptosis (43, 44).