Finally, though the association of methylations with the tumor prognosis were shown in no more than six cancer types, among which 5/6, 3/4, 2/3, 1/2, and 2/5 of them showed positively in NRP1, AXL, SCARB1 ACE2 and TMPRSS2 respectively, indicating a good outcome at least 40% of these STGs methylations in malignancies. The gene discussed is TMPRSS2; the disease is cancer.