TMPRSS2 and cancer: In addition, the CNVs of the five STGs were all connected with their expressions in many tumors (SCARB1 most in 18 cancers, TMPRSS2 in 13 cancers, followed by AXL in 10 cancers, ACE2 in seven cancers and NRP1 in six cancers) and the majority of the associations showed positively, indicating that CNVs of STGs were normally associated with the up-regulation of STGs expression and were implicated in the promotion of tumor growth.