In addition, the increased expression of SCARB1 could promote cell transformation towards malignancy of clear cell renal cell carcinoma leading to poor prognosis of patients (45), while the over-expression of AXL could accelerate EGFR mutation and promote the metastasis, invasion or drug resistance of tumors such as lung cancer (46), colorectal cancer (47), pancreatic cancer (48) and prostate tumor (49). Here, EGFR is linked to familial pancreatic carcinoma.