For instance, circACTN4 functions as a sponge to eliminate miR-424-5p to upregulate and recruit Yes-associated protein 1 (YAP1), which exerts a positive effect on inducing Frizzled-7 (FZD7) and in turn facilitates the development of intrahepatic cholangiocarcinoma (48). This evidence concerns the gene YAP1 and intrahepatic cholangiocarcinoma.