Increased hepatic expression of fibrosis (Col1a1, (p=0.31) Col1a2 (p=0.51), Acta2 (p=0.05)), cell regeneration (Ccnd1 (p=0.002) and Ki67 (p=0.0005)) and HCC-associated genes (Afp (p=0.009) and H19 (p=0.12)) was observed in Tn housed, WD + CCl4 treated mice, compared to Ts housed counterparts (Supplementary Figures 7I, K). This evidence concerns the gene MKI67 and hepatocellular carcinoma.