Lastly, although prolonged MCD diet feeding of mice housed at Tn increased the hepatic expression of Col1a1 (p=0.02) and Col1a2 (p=0.01) (Supplementary Figure 4N), such induction did not yield robust histological differences in hepatic fibrosis at the conclusion of the study (Supplementary Figure 5E). Here, COL1A1 is linked to Hepatic fibrosis.