IL1B and diabetes mellitus: Additionally, IL-1β intervention dose-dependently promotes the phosphorylation of p38 in cultured fibroblasts, while SB203580 (a p38 inhibitor) countervails the effects of IL-1β on collagenase, MMPs, and TIMPs (43), suggesting that IL-1β takes part in delayed wound healing in DM by altering levels of ECM remodeling proteins through activating p38 signal.