TNF and diabetes mellitus: SP facilities the wound healing in DM rats through relieving inflammation, promoting fibroblast proliferation, promoting COL deposition and improving angiogenesis, which up-regulates the expressions of IL-10 and HO-1, down-regulates TNF-α, IL-1β, as well as MMP-9, and enhances neovascularization via elevating VEGF, TGF-β1, and eNOS (67).