Recently, Exendin-4 was reported to possesses potent wound healing activity in DM, which facilities the wound healing in spontaneously diabetic ZDF rats via attenuating inflammation, promoting fibroblast/myofibroblast activities, and augmenting total COL content via decreasing the CRP concentration and the level of MMP-9, as well as elevating the level of TIMP-1. Here, MMP9 is linked to diabetes mellitus.