PTGS2 and diabetes mellitus: Kirenol administration reverses the up-regulation of angiogenesis-associated genes MMP-2 and MMP-9 in wounds of STZ-induced DM rats, decreases inflammation-related genes NF-κB, cyclooxygenase-2 (COX-2), as well as iNOS, reduces the contents of malonaldehyde (MDA), while increases the activities of antioxidant enzymes, which result in the alleviation of oxidative trauma.