Kirenol administration reverses the up-regulation of angiogenesis-associated genes MMP-2 and MMP-9 in wounds of STZ-induced DM rats, decreases inflammation-related genes NF-κB, cyclooxygenase-2 (COX-2), as well as iNOS, reduces the contents of malonaldehyde (MDA), while increases the activities of antioxidant enzymes, which result in the alleviation of oxidative trauma. Here, NFKB1 is linked to diabetes mellitus.