Similarly, scoring of individual protein mRNA levels pre- and post-treatment tumor specimens (n=13) revealed increased scores in immune effector proteins (IFN-γ, granzyme B, perforin), immune suppressive proteins (TGFβ, FoxP3), and immune checkpoint regulatory proteins (PD-1, PD-L1, PD-L2) following treatment (Figure 7). The gene discussed is PRF1; the disease is neoplasm.