Previous researchers have found that in patients with NSCLC, the higher the methylation level of EPHB6, HS3ST2, DAL-1, and TMEM88 genes, the greater the risk of metastasis, while the lower methylation of the ELMO3 gene, the greater the risk of NSCLC metastasis. This evidence concerns the gene HS3ST2 and non-small cell lung carcinoma.