Secondly, RT can regulate the TME, effectively promote the infiltration of CD8+ T lymphocytes by increasing the levels of chemokines CXCL10 and CXCL16 in TME, and reducing immune-related suppressor cells in the tumor stroma, shifting the TME transition from cold tumor to the hot tumor (8, 9). This evidence concerns the gene CXCL16 and neoplasm.