Previous researchers have found that in patients with NSCLC, the higher the methylation level of EPHB6, HS3ST2, DAL-1, and TMEM88 genes, the greater the risk of metastasis, while the lower methylation of the ELMO3 gene, the greater the risk of NSCLC metastasis. The gene discussed is TMEM88; the disease is non-small cell lung carcinoma.