First, our arterial blood gas and electrolyte analysis revealed that the concentrations of Na+, HCO3−, BE, and cTCO2 were higher in TASK−/− mice than in TASK+/+ mice, and that the concentrations of K+ were lower, indicating that TASK−/− mice suffered from electrolyte disturbances and mild acid-base balance disorder. This evidence concerns the gene KCNK3 and disorder of acid-base balance.