The oral administration of di-iso-nonyl phthalate (DINP) aggravates allergic dermatitis tissue damage in sensitized mice, and researchers believe that DINP enhances the TRPA1 expression through NF-κB signaling, which increases the levels of IL-6 and T-helper type2 (Th2) cytokines (LaMotte, 2016; Kang et al., 2017). This evidence concerns the gene TRPA1 and atopic eczema.