TRPA1 and Sepsis: In the renal tissues of IR injury, tubular epithelial cells slough off, inflammatory cells infiltrate, and a series of inflammatory responses appear (Wu et al., 2019) demonstrated that TRPA1-KO mice aggravated renal IR injury (Ma and Wang, 2021) Inflammation, microcirculation dysfunction, and metabolic remodeling are the pathogenesis of acute kidney injury in sepsis.