We report on a case of metastasectomy of solitary liver tumor after radical prostatectomy.<h4>Case presentation</h4>An 80-year-old man underwent radical prostatectomy for prostate cancer, followed by radiotherapy after the operation because of increased serum prostate-specific antigen levels of 0.529 ng/mL. This evidence concerns the gene KLK3 and Familial prostate cancer.