Tripterygium wilfordii lactone, the active ingredient of Tripterygium wilfordii[30, 31], inhibited cell growth and inflammatory response of RA-associated fibroblasts, such as synovial cells, by regulating the expression of the hsa-circ-0003353/microRNA-31-5p/cyclin-dependent kinase 1 axis [32]. The gene discussed is CDK1; the disease is rheumatoid arthritis.