HCG11 and neoplasm: To ravel out the potential role of HCG11 in CRC, we first predicted the expression of HCG11 in colon adenocarcinoma (COAD) on UALCAN (http://ualcan.path.uab.edu/index.html), and the result noted that HCG11 expression was higher in tumor tissues in comparison with normal tissues (p = 1.202370E − 02, Figure S1A).