The main aim in the current study was to investigate the impacts of HCG11 on biological behaviors of CRC cells in vitro and to explore the putative ceRNA network involving HCG11, microRNA-26b-5p (miR-26b-5p), and cAMP-regulated phosphoprotein 19 (ARPP19) in CRC cells. The gene discussed is HCG11; the disease is colorectal carcinoma.