TNF and cancer: KEGG analysis of key targets of SB for hepatocellular carcinoma showed that the key targets were enriched in a total of 238 pathways, including those in various cancers, such as small cell lung cancer and colorectal cancer, involving hepatitis B, hepatitis C, Epstein–Barr virus, influenza A and PI3K-Akt signaling pathway, AGE-RAGE signaling pathway in diabetic complications, IL-17 signaling pathway, TNF signaling pathway, and p53 signaling pathway.