The bubble plots are sorted by the gene ratio, the higher the number of genes in the top pathway, the larger the corresponding bubble in the plot, as shown in Figure B. JUN, RELA, and AKT1 were ranked in the top 5 of the core genes of the PPI network, which indicated that JUN, RELA, and AKT1 might be the key targets of SB for the treatment of hepatocellular carcinoma. The gene discussed is RELA; the disease is hepatocellular carcinoma.