Previous studies have demonstrated that wogonin induces apoptosis in hepatocellular carcinoma cells through intracellular H2O2 production and Ca2+ release [27], Wang et al. demonstrated that baicalein induces apoptosis and autophagy in hepatocellular carcinoma cells through endoplasmic reticulum stress [28], and Huang et al. demonstrated that wogonin induces apoptosis by regulating PI3K-AKT signaling in breast cancer cells [29]. The gene discussed is AKT1; the disease is breast cancer.