This is in line with the current Dutch guidelines, recommending PCa screening for first-degree relatives of patients from families with familial PCa starting at 50 yr of age (or 5 yr before the age of the youngest diagnosed PCa patient in the family) or for BRCA2 (L)PV carriers starting from 45 yr of age (or 5 yr before the age of the youngest diagnosed PCa patient in the family) [11]. Here, BRCA2 is linked to posterior cortical atrophy.