CGA and diabetes mellitus: CgA is present in the secretory granules of different neuroendocrine tissues and is an acidic protein prohormone recognized as a marker of mental stress.33 It is primarily stored in the vesicles of the adrenal glands and released into the circulation along with catecholamines through exocytosis.34 The level of CgA is higher in normal subjects at night and lower in the morning.35 Meanwhile, the study by Broedbaek and Hilsted36 found that CgA is an important biomarker in diabetes.