LCLAT1 and fatty liver disease: The expression of Acyl-CoA:lysocardiolipin acyltransferase-1 (ALCAT1) was upregulated in an HFD-induced NAFLD mouse model, and its genetic ablation can restore mitophagy in isolated hepatocytes, improving mitochondrial architecture and mtDNA fidelity and preventing the onset of hepatic steatosis in mice [70].