The expression of Acyl-CoA:lysocardiolipin acyltransferase-1 (ALCAT1) was upregulated in an HFD-induced NAFLD mouse model, and its genetic ablation can restore mitophagy in isolated hepatocytes, improving mitochondrial architecture and mtDNA fidelity and preventing the onset of hepatic steatosis in mice [70]. The gene discussed is LCLAT1; the disease is metabolic dysfunction-associated steatotic liver disease.