MLXIPL and Hyperinsulinemia: Secondly, hyperinsulinemia in response to IR in hepatocytes drives the synthesis of fatty acids within the hepatocytes via a process known as “de novo lipogenesis.” This process is regulated by two transcriptional factors: sterol regulatory element-binding protein 1c (SREBP1c) and carbohydrate response element binding protein (ChREBP), which are activated in response to glucose/fructose-induced insulin release.