Pretreatment with auxin to deplete TOP2A had no effect on MYCMI-7–induced inhibition of MYC:MAX interactions in the cells as measured by isPLA (Fig. 5B and C), nor did auxin treatment of HCT116TOP2A_mAID cells or siRNA-mediated knockdown of TOP2A in MDA-MB-231 breast cancer cells affect the growth-inhibitory effect of MYCMI-7 (Fig. 5D; Supplementary Fig. S4D), arguing against a mechanistic involvement of TOP2A in the action of MYCMI-7. Here, TOP2A is linked to breast carcinoma.