It also led to massive induction of apoptosis/necrosis and reduced tumor cell proliferation, which are typical outcomes when MYC is inactivated in transgenic mouse tumor models with inducible MYC (49, 57–59), as well as after treatment with MYCMI-6, 10008-F4, and with Mycro3 (8, 54, 60). Here, MYC is linked to neoplasm.