Analysis of the CD8 T-cell population (Fig. 1F) also showed a significantly higher proportion of naïve/SCM T cells in HDs (36.6 ± 6.8%) compared with newly diagnosed or patients with relapsed multiple myeloma (5.1 ± 2.0% and 4.4 ± 1.2%, respectively, P < 0.05) with no significant differences for the other T-cell populations. Here, CD8A is linked to AL amyloidosis.