ChT: chemoterapy; DLL-3: delta-like protein 3; mCPRPC: metastatic castration-resistant prostate cancer; MMAE: monomethyl auristatin E; ORR: overall response rate; OS: overall survival; PCa: prostate cancer; PSA: prostate-specific antigen; PSMA: prostate-specific membrane antigen; STEAP-1: six-transmembrane epithelial antigen of prostaZte-1; TF: tissue factor; Trop-2: trophoblast cell surface antigen-2. Here, DLL3 is linked to posterior cortical atrophy.