A study on diabetes found that the MAPK/NF-κB pathway is abnormally activated; however, U0126 inhibits the MAPK/NF-κB pathway and has a protective effect on pancreatic β cells, providing a new treatment strategy for the treatment of diabetes.36–38 Abnormal activation of the ectopic endometrium is closely related to ectopic endometrial proliferation and aggressive enhancement of EMs.39,40 In EMs, U0126 and BAY11-7082 protect EMs by inhibiting the MAPK/NF-κB pathway. Here, NFKB1 is linked to diabetes mellitus.