ELAVL1 and glaucoma: Based on our in vitro and in vivo findings, we conclude that HuR is essential for the efficient endogenous and exogenous neuroprotection of RGCs and that the induced alteration in the HuR content accelerates both the age-related and glaucoma-induced decreases in the RGC number and function, further confirming the key role of HuR in maintaining cellular homeostasis and its involvement in the pathogenesis of glaucoma.