In support of these data, in vitro studies have shown that P-selectin glycoprotein ligand (PSGL)-1, the major P-selectin ligand, is involved in rolling of CD8+ T cells isolated from MS patients and contributes to the transendothelial migration of MS-derived CD4+ T cells (Battistini et al., 2003; Bahbouhi et al., 2009). This evidence concerns the gene SELPLG and myeloid sarcoma.