Cellular adhesion molecules (CAM) belonging to the immunoglobulin superfamily such as vascular CAM-1 (VCAM-1), intercellular CAM-1 (ICAM-1), activated leukocyte CAM (ALCAM), and platelet endothelial CAM-1 (PECAM-1) are upregulated on the CNS vasculature, enhancing leukocyte adhesion and migration to the brain in both EAE and MS (Steffen et al., 1994; Cayrol et al., 2008; Steiner et al., 2010; Greenwood et al., 2011; Wimmer et al., 2019). This evidence concerns the gene ALCAM and myeloid sarcoma.