LncRNA HAND2-AS1 and CTD-2033D15.2 are gradually downregulated from the normal main pancreatic duct to low-grade IPMN, high-grade IPMN, and invasive IPMN, while LncRNA-TFG is gradually upregulated. This evidence concerns the gene HAND2 and pancreatic intraductal papillary-mucinous neoplasm.