Acute megakaryoblastic leukemia (AMKL) is categorized as acute myeloid leukemia (AML) M7 in the FAB classification (1) and defined by differentiation as blasts expressing at least one or more of the platelet glycoproteins: CD41 (glycoprotein IIb), CD61(glycoprotein IIIa), or CD42b (glycoprotein Ib) in the WHO classification (2). This evidence concerns the gene ITGB3 and acute megakaryoblastic leukemia.