Since AMKL leukemia cell has distinct origins of megakaryocyte progenitors, the immunophenotypic profile of AMKL often showed positive for at least one of the platelet glycoproteins: CD41, CD61, or CD42, which have generally not been seen in other subtypes of pediatric AML (29, 30). This evidence concerns the gene ITGB3 and acute myeloid leukemia.