In addition, the use of serum interleukin-1β (IL-1β), interleukin-6 (IL-6), and interleukin-8 (IL-8) in combination with carcinoembryonic antigen (CEA) as a biomarker panel for the detection and prediction of lung cancer metastasis are being studied (40). This evidence concerns the gene CEACAM5 and lung carcinoma.