To verify and clarify these specific correlations in our cohort of Chinese CLL patients, we performed fluorescence in situ hybridization (FISH), karyotype analysis, and targeted next-generation sequencing (NGS) for gene mutations, combined with Sanger sequencing or NGS, to identify clonal B-cell immunoglobulin heavy chain (IGH) gene rearrangements and to assess the extent of somatic hypermutation (SHM) in the IGHV sequence in 71 CLL patients in our center. The gene discussed is SLC3A2; the disease is B-cell chronic lymphocytic leukemia.