Human epidermal growth factor 2 (HER2) is a transmembrane glycoprotein that is expressed in several CNS tumors including GBM, ependymoma, and medulloblastoma, but no expressed in normal brain tissue, making it an appealing target for immunotherapy given on-target specificity with limited off-target potential toxicity (30). Here, ERBB2 is linked to glioblastoma.