The combination of tumor antigens and antibodies have been reported in PAULA’s test, a panel of 3 serum proteins (CEA, CYFRA21-1, and CA125) and 1 autoantibody (NY-ESO-1 AAB) was used to assist with the detection of lung cancer with 74% sensitivity, 80% specificity, and 0.81 AUC, respectively (20). The gene discussed is CEACAM5; the disease is lung cancer.