CD274 and cancer: Regarding KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analysis, pathways relating to cellular senescence, hippo signaling pathway, NOD (Nucleotide oligomerization domain)-like receptor signaling pathway, and PD-L1 (Programmed death ligand-1) expression/PD-1(Programmed death-1) checkpoint pathway in cancer had more SNP/InDel mutations in LSD members compared to these in LSN members (Figure 5).