We found that irrespective of STS-PLE I type or STS-PLE II type, all cases shared the following basic features: 1) the lower the Ki-67 index (<16%) and the younger the patient, the longer the survival was, especially in the case of STS-PLE I type; 2) the stronger the positive expression of CD31, CD34, c-myc, and ERG were, the shorter the ST was; and 3) The expression of D2-40 was positive in nearly all cases and the distribution of P53 was scattered, so it could not show association between both types. The gene discussed is TP53; the disease is telomere syndrome.