We found that irrespective of STS-PLE I type or STS-PLE II type, all cases shared the following basic features: 1) the lower the Ki-67 index (<16%) and the younger the patient, the longer the survival was, especially in the case of STS-PLE I type; 2) the stronger the positive expression of CD31, CD34, c-myc, and ERG were, the shorter the ST was; and 3) The expression of D2-40 was positive in nearly all cases and the distribution of P53 was scattered, so it could not show association between both types. This evidence concerns the gene ERG and telomere syndrome.