Unexpectedly, although the result were not statistically significant in the meta-analysis of high expression of CAFs and tumor size in gastric cancer (P=0.07), in the subgroup analysis, we found a significant association between α-SMA and tumor diameter >5 cm (RR, 1.47; 95% CI: 1.07–2.02; P=0.02) (Figure 11). The gene discussed is ACTA1; the disease is neoplasm.