Subgroup analysis of high expression of CAFs and stage III–IV gastric cancer showed that FAP (RR, 2.06; 95% CI: 1.14–3.74; P=0.02)was more closely related to stage III-IV gastric cancer than α-SMA (RR, 1.43; 95% CI: 1.07–1.92; P=0.01) (Figure 10). This evidence concerns the gene ACTA1 and gastric cancer.